10 Best Tretinoin Creams for Acne in 2022

With so many options, finding the best tretinoin cream for acne can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best tretinoin cream for acne. Let’s have a look.

Top 10 Best Tretinoin Creams for Acne

Bestseller No. 1
La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Prescription-Strength Topical Retinoid Cream For Face, Helps Clear and Prevent Acne and Clogged Pores
  • This once daily acne treatment with adapalene gel 0.1% helps clear and prevent blackheads, whiteheads, acne blemishes and clogged pores. Dermatologist developed and tested
  • The first prescription-strength topical retinoid for acne available without a prescription
  • Adapalene gel 0.1% helps prevent new acne from forming and helps clear blackheads, whiteheads, acne blemishes & clogged pores
  • Adapalene Gel 0.1% (Topical Retinoid): A topical retinoid medication used in Effaclar Adapalene for the treatment of acne. It works by regulating skin cell turnover to help remove and prevent dead skin from clogging pores
  • To open the product, remove the cap and insert the opposite side of the cap into the foil. Push down on the cap and twist until the foil is punctured. After using a gentle cleanser, apply a pea sized amount all over the face once daily in the evening
Bestseller No. 2
La Roche-Posay Effaclar Dermatological 3 Step Acne Treatment System, Salicylic Acid Acne Cleanser, Pore Refining Toner, and Benzoyl Peroxide Acne Spot Treatment for Sensitive Skin, 2-Month Supply
  • The only acne kit with Effaclar Duo, recommended by dermatologists, to reduce up to 60% of acne in just 10 days with visible results starting day 1. Reduces upto 60 percent of acne in 10 days
  • Formulated with dermatological acne treatment ingredients to reduce blackheads, whiteheads, and pimples.
  • Oil free formula that targets the major causes of acne as observed by dermatologists. 3-time winner of Allure’s Best of Beauty Award for Best Acne Treatment.
  • Formulated with Salicylic Acid, Glycolic Acid and Benzoyl Peroxide (BPO)
  • Contains: Acne wash/acne cleanser, acne facial toner, acne spot treatment cream
SaleBestseller No. 3
Acne Treatment Differin Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube
  • Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
SaleBestseller No. 4
Acne Treatment Differin Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Pump
  • Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
SaleBestseller No. 5
Ebanel Liposomal 2.5% Retinol Cream for Face with Hyaluronic Acid, Peptides, 3.5 Oz Pore Minimizer Skin Tightening Anti Wrinkle Cream for Face, Minimizes Fine Lines, Dark Spots, Age Spots, Acne Scars
  • MINIMIZES WRINKLES & FINE LINES - Our retinol anti wrinkle face cream works at a cellular level to stimulate collagen production and cellular renewal, slow down the natural aging process and rejuvenate skin
  • SMOOTHES & FIRMS SKIN TEXTURE, BRIGHTENS & EVENS SKIN TONE - Enriched with Peptides, our anti aging cream helps repair aged or damaged skin cells. This retinol moisturizer resurfaces dull skin by exfoliating at a cellular level
  • MINIMIZES BLEMISHES & ACNE - Our retinol acne cream stops pores from clogging, prevents pimples, blackheads, and cysts from forming, and minimizes breakouts. This skin tightening cream for face also helps balance oil level, decrease redness, and increase skin elasticity
  • EFFECTIVE DARK SPOT CORRECTOR FOR FACE - Our retinol night cream helps fade dark spots, age spots, sun spots, and skin discoloration; restore radiance for healthy, younger look
  • PERFECT EYE WRINKLE CREAM & NECK CREAM - Our retinol eye cream helps minimize eye bags, puffiness, dark circle, crow’s feet and milia. Also works great for neck, hand, arm and leg. Formulated & bottled in the USA! Never tested on animals - Cruelty-Free & Vegan-Friendly! cGMP Certified, Hypoallergenic, Paraben-Free, Sulfate-Free
SaleBestseller No. 6
CeraVe Retinol Serum for Post-Acne Marks and Skin Texture | Pore Refining, Resurfacing, Brightening Facial Serum with Retinol and Niacinamide | Fragrance Free, Paraben Free & Non-Comedogenic| 1 Oz
  • [ ACNE RETINOL SERUM FOR FACE ] With encapsulated retinol, this serum helps skin look smoother and more even-toned. Pore-minimizing serum for face helps refine skin’s texture over time and helps visibly reduce the appearance of post-acne marks.
  • [ LIGHTWEIGHT SERUM ] Gel texture & a non-greasy feel. Apply Resurfacing Retinol Serum at night & apply sunscreen. Apply a pea-sized amount of CeraVe retinol serum in a thin layer and allow to fully absorb into skin before applying additional products.
  • [ BRIGHTENING SERUM ] Formulated with licorice root extract helps to brighten the appearance of skin and niacinamide helps to calm skin. Fragrance free, paraben-free, and non-comedogenic.
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products, formulated with three essential ceramides (1, 3, 6-II)to help maintain the skin’s natural barrier.
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.
Bestseller No. 7
MDacne – Retinol 0.5% and Niacinamide 4% Treatment Cream, Reduces Blemishes and Improves Skin Texture without Irritation
  • MDacne Retinol Treatment Cream: This unique Retinol treatment cream combines the magic of high-strength 0.5% Retinol and 4% Niacinamide to help reduce blemishes, target fine wrinkles and uneven skin tone, and to help improve the skin’s texture for more youthful-looking skin. 0.7 fl oz.
  • Ingredients That Work: Pure Retinol works to help unclog pores and prevent acne blemishes and fine wrinkles without over-drying the skin. Niacinamide, or Vitamin B3, is a powerful anti-inflammatory ingredient that supports skin hydration and improved skin texture and helps fade post-acne dark spots.
  • Treatment Boosters: Tea tree oil is known to work efficiently against acne. Aloe Vera, Chamomile and Calendula Officinalis extracts are compounds that are known to hydrate skin, soothe irritation, and reduce redness. Sunflower extract exhibits anti-glycation properties and Licorice extract helps prevent and fade brown spots.
  • All-Natural & Good-For-You: MDacne Retinol Treatment Cream is dermatologist designed and approved and made in the USA. Free from parabens, sulfates, silicone, and gluten. Non-toxic, vegan, and cruelty-free.
  • A Different Approach: We founded MDacne to create a more effective and affordable way to treat acne. We’re on a mission to help clear your skin in an easier, faster, and more pleasant way than anything you’ve tried before.
Bestseller No. 8
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment, Blemish Cream for Acne and Blackheads, Safe For Sensitive Skin
  • La Roche Posay's best spot treatment for acne reduces the number and severity of acne blemishes, pimples, blackheads and whiteheads
  • Formulated with 5.5% micronized benzoyl peroxide and micro-exfoliating lipo-hydroxy acid (LHA), this acne spot treatment provides fast and visible results in less than 3 days.
  • Acne spot treatment reduces 60% of acne in 10 days with dual action that reduces the number and severity of blemishes and clears blackheads/whiteheads
  • Treats skin concerns like red, raised pimples, blackheads, whiteheads, clogged pores, and sensitive skin. Can be used as acne spot treatment or all over face.
  • Can be used as a spot treatment or all over face. Approved for ages 13 and up and safe for sensitive skin. Non drying, oil free, fast absorbing texture
Bestseller No. 9
Cystic, Hormonal, and Severe Acne Treatment Cream for Teens & Adults Acne Treatment with Special Anti Acne Ingredients designed in USA and formulated in Japan (100ml/3.38oz)
  • Advanced Cystic Acne Treatment: Our cystic acne treatment cream reduces cystic acne and pimples, specially developed for all types of acne skin, gentle, moisturizing, and repairing by reducing oil production, speeding up skin cell turnover, soothing and reducing inflammation, which helps to prevent scarring.
  • A Unique Balanced Formula: cystic acne treatment cream contains Antibacterial, Anti-Acne ingredients that were carefully selected by professionals! SUNHEAL acne cream also includes Moisturizing and Repairing ingredients to help smooth and soften skin!
  • High Quality and Really Work: Our Acne Cream was designed in the US and formulated in Japan according to the strict standards. This cystic acne treatment cream doesn't contain any GMOs, artificial colors,! Remove pimples from your skin with our fast-absorbing face moisturizer for acne prone skin.
  • Directions For Use: Take an appropriate amount of this Cystic Acne Treatment Cream and apply it evenly on the acne-producing area of ​​the face and body like Back,Hip,,Chest,Neck,Shoulders andUpper arms.Apply it 3-4 times a day, or apply it 4-6 times if it is a serious condition for 4 weeks at least.
  • Positive Experience Guaranteed: We stand for your satisfaction with our products. We hope that you enjoy our acne treatment cream.Forget about breakouts and cystic acne, start to treat your skin right with Acne Treatment!
Bestseller No. 10
ACNEtane | Acne Pills for Cystic Acne | Hormonal Acne Treatment with Vitamin Complex & L-Carnitine | All-Natural Non-GMO Supplements for Teens & Adults | 180 Vegan Capsules
  • ✅GET RID OF ACNE: Finally, the answer you've been looking for to reduce Cystic Acne breakouts on your face, body and back. ACNEtane works by giving your body an effective blend of Vitamins, Minerals, Amino Acids, and antioxidants to supercharge your skin keeping it less oily and keeping Hormonal Breakout at bay.
  • ✅POWERFUL INGREDIENTS: Only the top ingredients (Including Vitamin B5, L-Carnitine, Co-enzyme Q10, Vitamin A, amongst others) in the perfect dosage to clear pimples, blackheads and bumps associated with Hormonal Cystic Acne. Each ingredient is specifically chosen for its known impact on skin health and Acne in adult males, females, and adolescents.
  • ✅DECREASE OIL PRODUCTION: This Natural skin supplement improves skin healing time, and the ability to regulate hormonal breakouts. Provides an INTERNAL DEFENSE by disintegrating pore-clogging oils without over-drying your skin to effectively reduce future breakouts.
  • ✅ALL NATURAL & EFFECTIVE FORMULA: Formulated in a GMP Certified Facility. Nutriissa's ACNEtane is completely free of fillers, binders, or artificial ingredients with NO unwanted side effects. This is as clean and pure as it gets!
  • ✅CONFIDENCE BOOSTER: Boost your confidence & become the best version of YOURSELF with this acne pill containing Natural Ingredients NOT talked about by Big Pharma! PLEASE COMPARE OUR INGREDIENTS TO THE BEST SELLERS IN THIS CATEGORY, WE BEAT THEM IN EVERY WAY!

Things to Consider When Buying the Best Tretinoin Creams for Acne

Ingredients

When it comes to choosing the best tretinoin cream for acne, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a tretinoin cream.

Price

Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best tretinoin cream for acne.

Avoid Harsh Chemicals

When looking for the best tretinoin cream for acne, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best tretinoin cream for acne, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best tretinoin cream for acne. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the tretinoin cream you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which tretinoin cream you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.

Conclusion

It can be challenging to find the best tretinoin cream for acne. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best tretinoin cream for your needs.

Which one of these tretinoin creams are you going to try? Let us know in the comments below. If you have any questions, ask away.

Leave a Comment