10 Best Tretinoin Creams for Acne in 2022

With so many options, finding the best tretinoin cream for acne can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best tretinoin cream for acne. Let’s have a look.

Top 10 Best Tretinoin Creams for Acne

Bestseller No. 1
La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Prescription-Strength Topical Retinoid Cream For Face, Helps Clear and Prevent Acne and Clogged Pores
  • This once daily acne treatment with adapalene gel 0.1% helps clear and prevent blackheads, whiteheads, acne blemishes and clogged pores. Dermatologist developed and tested
  • The first prescription-strength topical retinoid for acne available without a prescription
  • Adapalene gel 0.1% helps prevent new acne from forming and helps clear blackheads, whiteheads, acne blemishes & clogged pores
  • Adapalene Gel 0.1% (Topical Retinoid): A topical retinoid medication used in Effaclar Adapalene for the treatment of acne. It works by regulating skin cell turnover to help remove and prevent dead skin from clogging pores
  • To open the product, remove the cap and insert the opposite side of the cap into the foil. Push down on the cap and twist until the foil is punctured. After using a gentle cleanser, apply a pea sized amount all over the face once daily in the evening
Bestseller No. 2
Acne Treatment Differin Gel, 30 Day Supply, Retinoid Treatment for Face with 0.1% Adapalene, Gentle Skin Care for Acne Prone Sensitive Skin, 15g Tube (Packaging May V
  • Clears breakouts where they start (Deep in pores) and prevents new acne from forming, which ultimately restores skin's texture and tone
  • Differin works differently than other Acne treatments by normalizing skin cell turnover and effectively targets two primary causes of Acne, clogged pores and inflammation
  • Adapalene was created for superior tolerability compared to other prescription retinoid products not containing Adapalene; It is suitable for use as part of your morning or evening regimen
  • Water based formula, oil free, alcohol free, fragrance free, non comedogenic; Helps reduce the risk of scarring and Hyperpigmentation by treating Acne
  • In a clinical study, Differin gel provided up to 87 percent reduction in acne breakouts after 12 weeks, which will continue to improve with further use
Bestseller No. 3
Retinol Gel 0.1 Vitamin A Repairs Fine Lines & Wrinkles, Scar Treatment, Age and Sun Spots, Anti-Aging Formula , 20 Grams
  • Retinol 0.1 Gel treats wrinkles, fine lines, age and sunspots. It is also capable of treating various skin hyperpigmentation conditions such as melasma, freckles, darker and lighter spots on the photodamaged skin.
  • It is a non-oily, fast absorber and deep penetrating skin treatment. It helps the skin to renew itself by preventing the spread and formation of pimples, blackheads and whiteheads.
  • It treats acne and wrinkles by peeling off dead skin cells, smoothing rough facial skin and reducing mottled skin discoloration.
  • The gel is used to prevent and treat pimples. It also reduces the occurrence of new pimple breakouts and promotes the healing of the skin. Wrinkled and rough/mottled skin: The gel is used to treat wrinkles and patchy skin colour associated with excess UV exposure.
  • Directions for Use- Wash the area to be applied with warm soapy water or a soap-free cleanser and rinse with water. Remove all cosmetics before applying a gel. Gently dry the area and wait for 15 minutes to make sure the skin surface is completely dry. Squeeze a small amount of gel on your fingertip. Apply the gel to the affected area once a day, preferably in the evening or just before the bedtime.
Bestseller No. 4
CeraVe Retinol Serum for Post-Acne Marks and Skin Texture | Pore Refining, Resurfacing, Brightening Facial Serum with Retinol and Niacinamide | Fragrance Free, Paraben Free & Non-Comedogenic| 1 Oz
  • [ ACNE RETINOL SERUM FOR FACE ] With encapsulated retinol, this serum helps skin look smoother and more even-toned. Pore-minimizing serum for face helps refine skin’s texture over time and helps visibly reduce the appearance of post-acne marks.
  • [ LIGHTWEIGHT SERUM ] Gel texture & a non-greasy feel. Apply Resurfacing Retinol Serum at night & apply sunscreen. Apply a pea-sized amount of CeraVe retinol serum in a thin layer and allow to fully absorb into skin before applying additional products.
  • [ BRIGHTENING SERUM ] Formulated with licorice root extract helps to brighten the appearance of skin and niacinamide helps to calm skin. Fragrance free, paraben-free, and non-comedogenic.
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products, formulated with three essential ceramides (1, 3, 6-II)to help maintain the skin’s natural barrier.
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.
SaleBestseller No. 5
MDacne – Retinol 0.5% and Niacinamide 2% Treatment Cream, Reduces Blemishes and Improves Skin Texture without Irritation
  • MDacne Retinol Treatment Cream: This unique Retinol treatment cream combines the magic of high-strength 0.5% Retinol and 2% Niacinamide to help reduce blemishes, target fine wrinkles and uneven skin tone, and to help improve the skin’s texture for more youthful-looking skin.
  • Ingredients That Work: Pure Retinol works to help unclog pores and prevent acne blemishes and fine wrinkles without over-drying the skin. Niacinamide, or Vitamin B3, is a powerful anti-inflammatory ingredient that supports skin hydration and improved skin texture and helps fade post-acne dark spots.
  • Treatment Boosters: Tea tree oil is known to work efficiently against acne. Aloe Vera, Chamomile and Calendula Officinalis extracts are compounds that are known to hydrate skin, soothe irritation, and reduce redness. Sunflower extract exhibits anti-glycation properties and Licorice extract helps prevent and fade brown spots.
  • All-Natural & Good-For-You: MDacne Retinol Treatment Cream is dermatologist designed and approved and made in the USA. Free from parabens, sulfates, silicone, and gluten. Non-toxic, vegan, and cruelty-free.
  • A Different Approach: We founded MDacne to create a more effective and affordable way to treat acne. We’re on a mission to help clear your skin in an easier, faster, and more pleasant way than anything you’ve tried before.
Bestseller No. 6
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment, Blemish Cream for Acne and Blackheads, Safe For Sensitive Skin, 1.35 Fl Oz (Pack of 1)
  • La Roche Posay's best spot treatment for acne reduces the number and severity of acne blemishes, pimples, blackheads and whiteheads
  • Formulated with 5.5% micronized benzoyl peroxide and micro-exfoliating lipo-hydroxy acid (LHA), this acne spot treatment provides fast and visible results in less than 3 days.
  • Acne spot treatment reduces 60% of acne in 10 days with dual action that reduces the number and severity of blemishes and clears blackheads/whiteheads
  • Treats skin concerns like red, raised pimples, blackheads, whiteheads, clogged pores, and sensitive skin. Can be used as acne spot treatment or all over face.
  • Can be used as a spot treatment or all over face. Approved for ages 13 and up and safe for sensitive skin. Non drying, oil free, fast absorbing texture
Bestseller No. 7
Ebanel 2.5% Retinol Cream for Face Moisturizer with Peptides, Hyaluronic Acid, Anti Aging Wrinkle Night Cream, Skin Tightening Firming Cream for Face and Neck, Minimizes Dark Spot, Age Spot, Acne Scar
  • Fine Line & Wrinkle Remover for Face and Body - Our retinol moisturizer face cream works at a cellular level to boost collagen production and rejuvenate skin. Effective anti-wrinkle cream for women and men, deep wrinkle filler for face, forehead, and under-eye areas
  • Face Tightening and Lifting Cream - Our retinol anti-aging cream helps slow down natural aging process, repair aging skin, and smooth and soften skin texture. This retinol peptide moisturizer resurfaces dull skin by exfoliating gently at a cellular level, and accelerates skin turnover
  • Blemish, Acne & Pore Minimizer - Our retinol acne moisturizer for face unclogs pores and prevents pimples, blackheads, cysts, and breakouts. This anti-redness face cream also helps balance oil levels and increase skin elasticity
  • Effective Dark Spot Remover for Face - Our retinol cream helps fade dark spots, age spots, sun spots, and skin discoloration. This skin brightening cream for face evens skin tone and restores radiance for a healthy, younger look
  • Formulated & Bottled in the USA - Can be used as neck firming cream and anti-aging hand cream, may use as retinol eye cream based on skin tolerance. Never tested on animals - Cruelty-Free & Vegan-Friendly! cGMP Certified, hypoallergenic, non-comedogenic, mineral oil-free, and paraben-free
Bestseller No. 8
Youngerful Premium Under Eye Cream - Day and Night Anti Aging Face Moisturizer for Women - Collagen Cream with Snail Mucin Extract - Pure Hyaluronic Acid for Face - Korean Skin Care Snail Cream
  • FOR ALL SKIN TYPES: Our moisturizers for face and neck is safe for sensitive skin. Regular use of this wrinkle cream for face can give your skin a smoother texture and reduce pigmentation and discoloration.
  • POWERFUL FORMULA: Youngerful day and night cream for face with hyaluronic acid, collagen, and SNAIL EXTRACT will hydrate and moisturize your skin. Snail repair cream targets cell rejuvenation, fine lines and wrinkles, and uneven texture.
  • READILY ABSORBED: Thanks to its oil-free formula, our collagen hyaluronic acid snail white cream is a non-greasy and will be easily absorbed.
  • COMPACT 1.35 OZ PUMP BOTTLE: This facial moisturizer comes in an easy-to-use pump bottle that reduces waste. Thanks to the air-tight packaging, the quality of the cream will not deteriorate on the go.
  • HAPPY CLIENTS: 94% reported improvements in skin texture, 87% saw fewer wrinkles, and 85% said their necks were firmer in just three weeks. Order our anti-wrinkle cream NOW to improve your skin’s beauty and health.
SaleBestseller No. 9
CeraVe Skin Renewing Night Cream | Niacinamide, Peptide Complex, and Hyaluronic Acid Moisturizer for Face | 1.7 Ounce, Packaging may Vary
  • [ PEPTIDE COMPLEX ] Help reduced the look of fine lines and wrinkles while supporting skin elasticity
  • [ OVERNIGHT MOISTURIZER ] Helps soften, hydrate and retain skin's moisture with hyaluronic acid. Renew the look of tired skin overnight. This skin care product does not come with a protection inner seal.
  • [ GENTLE ON SKIN ] Fragrance free, non-comedogenic, and non-irritating formula
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.
SaleBestseller No. 10
CeraVe Anti Aging Retinol Serum | Cream Serum for Smoothing Fine Lines and Skin Brightening | With Retinol, Hyaluronic Acid, Niacinamide, and Ceramides | 1 Ounce
  • [ RETINOL SERUM FOR FACE ] Anti-aging facial serum with Retinol to help improve skin’s texture including visible signs of aging for more radiant skin and Hyaluronic Acid to help retain skin’s natural moisture, and Niacinamide to help calm skin.
  • [ SMOOTH TEXTURE ] Lightweight serum with a gel texture and a non-greasy feel. If layering with an eye cream or facial moisturizer, apply Skin Renew Retinol Serum in a thin layer and allow to fully absorb into skin before applying additional products.
  • [ GENTLE ON SKIN ] Fragrance free, non-comedogenic, and non-irritating formula. As retinol can cause sun sensitivity, please apply Skin Renewing Retinol Serum at night or wear a facial moisturizer with at least SPF 30 sunscreen if wearing during the day.
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.

Things to Consider When Buying the Best Tretinoin Creams for Acne

Ingredients

When it comes to choosing the best tretinoin cream for acne, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a tretinoin cream.

Price

Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best tretinoin cream for acne.

Avoid Harsh Chemicals

When looking for the best tretinoin cream for acne, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best tretinoin cream for acne, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best tretinoin cream for acne. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the tretinoin cream you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which tretinoin cream you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.

Conclusion

It can be challenging to find the best tretinoin cream for acne. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best tretinoin cream for your needs.

Which one of these tretinoin creams are you going to try? Let us know in the comments below. If you have any questions, ask away.

Leave a Comment