10 Best Spot Treatments for Cystic Acne in 2022

With so many options, finding the best spot treatment for cystic acne can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best spot treatment for cystic acne. Let’s have a look.

Top 10 Best Spot Treatments for Cystic Acne

Bestseller No. 1
Cystic Acne Spot Treatment, 120+ Uses, Overnight Results Cystic Acne Treatment, Unique Formula with 3% Sulfur, Bentonite, & Tea Tree Oil, Works on Hormonal & Stubborn Acne, Cystic Acne, & Blackheads, by TreeActiv
  • Get The Acne-Free Skin You Need: Our cystic acne treatment with pure Tea Tree Oil for face now offers twice the amount for the same price, so you can combat more stubborn zits; add this acne minimizer to your regimen to achieve blemish-free skin fast
  • Your Instant Acne Remedy: Unlike other products, our adult and teen zit clay wastes no time; our Sulfur and Bentonite pimple spot treatment offers rapid results by unclogging pores and lessening the look of acne, leaving your skin clearer and fresher
  • No More Redness And Irritation: You don't need to suffer in pursuit of beauty, so use our pimple cream spot treatment to say bye to breakouts; with only plant-based ingredients, our zit cream eliminates acne-causing irritants without causing discomfort
  • Offers 120+ Treatments: A little goes a long way with our cleansing acne cream that shrinks zits in no time, you'll be surprised by the good results when you wake up; our proactive acne spot treatment for face and body is ideal for all skin types too
  • Directions For Use: Apply a tiny amount of our zit, whitehead, and blackhead clay; rinse after 15 minutes; for best results, leave it overnight and use it with our hydrating Acne Treatment Face Spray and gentle Acne Treatment Face Cream Moisturizer
SaleBestseller No. 2
Cystic Acne Spot Treatment, Hormonal Acne Treatment, Cystic Acne Treatment for Face and Body, with Salicylic Acid and Tea Tree Oil, Pimple Cream, Advanced Acne Cream for Teens & Adults
  • TACKLES CYSTIC ACNE--This cystic acne spot treatment effectively tackles cystic, hormonal, and severe acne. It's also a hormonal acne treatment cream, acne cream and pimple cream.
  • IMPROVED BOTTLE--Solution to the disadvantage of the traditional bottle, which caused the cream to dry out and harden. The new bottle design allows the cream to be used for an extended period of time without drying out.
  • NATURAL AND GENTLE FORMULA--containing salicylic acid, tea tree oil, aloe vera, and a variety of other natural active ingredients, gently works on acne and offers antibacterial as well as oil-control effects.
  • PRECAUTION OF ACNE REGROWTH-- preventing the new acne while treating the existing one(s).
  • HOW TO USE--After cleansing and toning, apply an appropriate amount of this Cystic Acne Treatment Cream thickly to the acne and leave it on overnight to wash off. Do not apply it over a large area and avoid the area around your eyes. Use 1-2 times a day ( with at least 4 hours between applications), 2-3 times for severe acne for 4 weeks at least. Continue to apply the cream even after the acne is no longer visible until there is no sign of regrowth.
SaleBestseller No. 3
TKTK Pimple Patches - 15mm Large Invisible Acne Patch for Face with Salicylic Acid, 0.01 cm Extra Thin Edges Daytime Use Hydrocolloid Zit Patch for Large Pustule, White Head, Cystic Acne Spot Treatment - 48 Count
  • Adhesive & Invisible Daytime Pimple Patch - 0.01cm ultra-thin beveled edges, super adhesive and barely noticeable for covering acne and zits, matte finish that fits perfectly under your makeup during the day
  • Easy to Cover Larger Pimples - 15mm largest round acne patches of TKTK helps hide the big blemishes that pop up on your face, such as pustules, whiteheads, zits, hormonal acne, adult acne and cystic acne
  • 6X Absorbent Hydrocolloid Sticker - Made with medical grade hydrocolloid, gently traps all the gunk from your pimples and prevents picking or popping. Non-irritating and safe on all skin types
  • Natural Salicylic Acid - Extracted from natural willow bark, strong ingredient that unclogs pores, diminishes redness and promotes healing of acne, more effective for daily acne treatment
  • Easy to Use - With easy to peel design, clean & dry the affected area, peel off the individually packaged acne patch and apply to the face in a more sanitary way for better results
Bestseller No. 4
Cystic Acne Spot Treatment, 2 pack, 240+ Uses, Overnight Results Cystic Acne Treatment Unique Formula with Sulfur, Bentonite, & Tea Tree Oil, Works on Hormonal & Stubborn Acne, Cystic Acne, & Blackheads, by TreeActiv
  • ✅Not Just One But Two: Our cystic acne spot treatment clay now offers a pack of 2 jars, so you can cover more stubborn acne wherever they are. A small amount is enough, so each jar of this hormonal acne treatment for face & body will last long.
  • ✅Your Instant Acne Remedy: Unlike other anti-acne products, our clearing pimple cream spot treatment with Bentonite Clay & Pure Tea Tree Oil for acne provides rapid & visible results by unclogging pores, removing dirt, & lessening the look of redness.
  • ✅Offers 120+ Treatments Per Jar: Little goes a long way with our fast-acting acne face cream that shrinks zits fast. With Peppermint Oil, Eucalyptus Oil, Lemon Oil, & Spearmint Oil, our bacne & acne spot treatment solution is gentle on all skin types.
  • ✅Quick-Absorbing Zit Prevention Clay: Our dark acne spot corrector with a natural formula gets absorbed into the skin fast. This nighttime solution for marks & blemishes works well with our Acne Treatment Face Cream Moisturizer
  • ✅Comes With Pimple Patches: Our Aloe Vera & Sulfur acne treatment for active breakouts comes with cleansing Hydrocolloid patches in 3 sizes. Each acne patch or sticker targets every zit, dot, bump, whitehead, and blackhead, ensuring you're acne-free.
Bestseller No. 5
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz
  • 1-ounce tube of Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with maximum-strength 10% benzoyl peroxide acne medication to help fight acne and prevent future breakouts for clearer looking skin
  • This effective acne-fighting spot gel is clinically proven to rapidly reduce the size and redness of stubborn acne in just 2 hours and actively fights breakouts, for continuous improvement in skin's appearance throughout the day
  • Its maximum strength formula contains 10% benzoyl peroxide, the acne medication dermatologists recommend most for clearer skin without a prescription
  • From a dermatologist recommended brand, this maximum-strength daily stubborn acne treatment is specially formulated for acne-prone skin to help manage acne and clear breakouts
  • Cleanse skin thoroughly before applying acne pimple spot treatment gel then proceed to cover affected area with a thin layer of acne gel 1 to 3 times daily
SaleBestseller No. 6
De La Cruz 10% Sulfur Ointment Cystic Acne Spot Treatment for Face and Body - Medication to Clear Pimples and Blackheads - Made in the USA
  • GOOD BYE BLEMISHES You will notice acne and overall skin improvement within just a few days! This fast action sulfur cream will leave your skin feeling smooth, less oily and blemish free!
  • STOP PIMPLES IN THEIR TRACKS Maximum strength cystic acne treatment penetrates the pores eliminating pimples and blackheads. It helps prevent any new pimple and blackhead from forming.
  • CLEARS ACNE ON THE SPOT Whether you have hormonal or severe cystic acne, blackheads or even acne scars, DLC's Sulfur Ointment is the best treatment
  • 10 MINUTE ACNE TREATMENT Apply a thin layer over your face, back or the affected area, wait 10-20 minutes and wash off with warm water. A consistent daily regimen will ensure the best results.
  • NEVER TESTED ON ANIMALS This effective acne ointment has been allergy tested and does not contain fragrance, parabens or artificial colors. It is non-comedogenic (does not clog pores). Made in USA.
Bestseller No. 7
Diva Stuff Cystic Acne Spot Treatment, Roller Ball, overnight Results – For Mild to Severe Acne with Salicylic Acid, Hawaiian Sea Extract, Hyaluronic Acid, Lactic Acid & Turmeric – Made in the USA
  • OVERNIGHT ACTION: Our fast absorbing formula heals acne by soothing inflammation, neutralizing acne-causing germs and shrinking pores. Specially designed to treat blemishes and cystic acne, this acne gel can be applied to forming and existing blemishes so that you can stop acne in its tracks.
  • UNIQUE, POWERFUL FORMULA: Contains Turmeric Hydrosol, Hawaiian Sea Extract, Tea Tree Oil, Wintergreen, Salicylic Acid, and more. We’ve blended some of the finest acne-busting ingredients to give your skin a royal skincare treatment. Salicylic Acid is known to reduce acne by unclogging pores and dissolving dead skin cells, while Turmeric is known to reduce inflammation and pimple scars.
  • MOISTURIZE SKIN WHILE FIGHTING ACNE: Hyaluronic Acid has shown to effectively keep skin surrounding acne from drying out. It’s also not known to clog pores because of its oil-free nature. We’ve blended Hyaluronic Acid into our acne spot treatment to exfoliate skin while delivering moisture and without causing dryness.
  • TEA TREE OIL, THE ACNE KILLER: Tea Tree Oil is well-known in the acne industry. It is traditionally used as a topical blemish shrinking and reducing agent.
  • THE DIVA STUFF GUARANTEE: At Diva Stuff, we live to create the best, most fun, and fairly priced beauty products possible. We are so confident that you'll love your Diva Stuff product that we stand by it 100%. We offer a lifetime satisfaction guarantee with each and every product we make.
SaleBestseller No. 8
DRMTLGY Acne Spot Treatment and Cystic Acne Treatment. Acne Serum with Micronized Benzoyl Peroxide 5% and Glycolic Acid
  • QUICKLY FIGHTS ACNE BACTERIA ON THE SPOT. Treats acne breakouts, reduces pimples, whiteheads, and blackheads within 24 hours. Dissolves pore-clogging oils without over-drying your skin to effectively reduce future breakouts.
  • CONTAINS THE PUREST FORM OF BENZOYL PEROXIDE 5%. United States Pharmacopeia (USP) grade Benzoyl Peroxide 5% penetrates deep within the pores, eliminating current breakouts and preventing new ones. Proven as one of the most effective acne-fighting ingredients.
  • GLYCOLIC ACID 5% REDUCES ACNE SCARRING. Glycolic Acid in the form of sugar cane gently exfoliates to increase cellular turnover and remove cellular debris. This allows for a clearer complexion with a reduction in scarring.
  • REDUCES THE OIL IN PORES UP TO 85%. This acne serum is effective on the face, chest, and back to unclog pores, reduces redness, and inflammation.
  • DERMATOLOGIST RECOMMENDED ACNE TREATMENT SERUM. Our acne serum is safe for these skin types: dry, oily, combination, and normal. This formula is also paraben free, sulfate free, and cruelty free.
Bestseller No. 9
BellamiLuxx Acne Treatment, Salicylic Acid Advanced Acne Spot Treatment Face, Natural Acne Cream Pimple Cream, Effective Hormonal Acne Treatment. Cystic Acne Cream - 100mL 1 3.52 Ounce 100.0 grams
  • Tackles Cystic Acne - Our Cystic Acne Treatment effectively tackles cystic acne and hormonal acne with its powerful ingredients.
  • Natural Fomula Acne Treatment - Our Cystic Acne Treatment (Salicylic Acid Acne Treatment for Face) formulated with tea tree oil and various natural plant extracts. This acne cream gently make the acne free, is excellent cystic acne treatment and pimple cream.
  • Fast-Acting Acne Spot Treatment - This Cystic Acne Treatment with concentrated formula, works fast to cure cystic acne, hormonal acne, milia, pimple, whitehead, and blackhead breakouts, penetrating into the pores to clear its root. This hormonal acne spot treatment is effective acne spot treatment.
  • Acne Prevention Acne Cream- Our pimple cream works on your skin from the inside, powerful acne moisturizer, prevent future acne breakouts.
  • Highly Recommended - This advanced hormonal acne treatment and blemish spot treatment is sure to give you maximum relief.
Bestseller No. 10
GRAMRIGHT Acne Patches - Natural Hydrocolloid Bandages for Acne Spot Treatment - Cystic Acne Cover Patches with Salicylic, Hyaluronic Acids and Tea Tree Oil - Pimple Patches for Face - 120 Patches
  • Acne Patches for Face - Finally, a powerful, invisible and easy acne scar remover for acne-prone skin! These clear and fast-acting hydrocolloid stickers will protect and cover pimples while pulling out any impurities and healing the skin. You can wear them during the day and night, and you’ll see the results in 7 hours!
  • Acne Spot Treatment - Our acne scar patches are waterproof and breathable, and they help prevent acne scars, cystic acne and new breakouts. They also absorb all the gunk and reduce redness & irritation. You can go on with your day or sleep the night, and your acne will stay covered & healed!
  • Hydrocolloid Bandages for Blemishes - Every Gramright Acne Patch is made from pure hydrocolloid, containing salicylic and hyaluronic acids. Salicylic acid treats acne and can have a drying effect, Hyaluronic acid hydrates the skin and helps it heal faster. Tea tree and arnica oils clear, heal and reduce breakouts.
  • Quality Acne Skincare - We use only potent and safe formulas for all Gramright products, and they are professionally formulated with strict manufacturing control. Our patches also stick well to the skin and don’t bunch up, so you can wear them for hours, stick them on and peel them off quickly.
  • Skin Happiness Guarantee - Here, at Gramright, we value your happiness and experience with our products above all else. If you are somewhat unsatisfied with our Acne Remover or have any questions, contact us directly - we will hear you out and make things right for you!

Things to Consider When Buying the Best Spot Treatments for Cystic Acne


When it comes to choosing the best spot treatment for cystic acne, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a spot treatment.


Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best spot treatment for cystic acne.

Avoid Harsh Chemicals

When looking for the best spot treatment for cystic acne, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best spot treatment for cystic acne, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best spot treatment for cystic acne. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the spot treatment you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which spot treatment you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.


It can be challenging to find the best spot treatment for cystic acne. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best spot treatment for your needs.

Which one of these spot treatments are you going to try? Let us know in the comments below. If you have any questions, ask away.

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