10 Best Spot Treatments for Acne in 2022

With so many options, finding the best spot treatment for acne can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best spot treatment for acne. Let’s have a look.

Top 10 Best Spot Treatments for Acne

Bestseller No. 1
Acne Free Terminator 10 Acne Spot Treatment with Benzoyl Peroxide 10% Maximum Strength Acne Cream Treatment, 1 Ounce - Pack Of 1
  • Fast, targeted Acne treatment for pimples, spots, and blemishes that appear unexpectedly and require a quick solution
  • Maximum concentration formula with 10 percent micronized Benzoyl Peroxide that rapidly penetrates deep into the pores to remove stubborn pimples, blackheads, and acne and prevent them from reoccurring
  • Natural caring ingredients like Ginger, and Chamomile soothe and care for skin
  • Treat + Care for your skin with the concentrated 10 percent Benzoyl Peroxide, a medicated acne topical spot remover that treats acne breakouts, and chamomile and ginger to soothe and calm acne prone skin
  • Apply a thin layer of terminator 10 to the affected area and rub all over to prevent further breakouts
Bestseller No. 2
Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with Maximum Strength 10% Benzoyl Peroxide Acne Treatment Medication, Pimple Cream for Acne Prone Skin Care, 1 oz
  • 1-ounce tube of Neutrogena Rapid Clear Stubborn Acne Spot Treatment Gel with maximum-strength 10% benzoyl peroxide acne medication to help fight acne and prevent future breakouts for clearer looking skin
  • This effective acne-fighting spot gel is clinically proven to rapidly reduce the size and redness of stubborn acne in just 2 hours and actively fights breakouts, for continuous improvement in skin's appearance throughout the day
  • Its maximum strength formula contains 10% benzoyl peroxide, the acne medication dermatologists recommend most for clearer skin without a prescription
  • From a dermatologist recommended brand, this maximum-strength daily stubborn acne treatment is specially formulated for acne-prone skin to help manage acne and clear breakouts
  • Cleanse skin thoroughly before applying acne pimple spot treatment gel then proceed to cover affected area with a thin layer of acne gel 1 to 3 times daily
Bestseller No. 3
La Roche-Posay Effaclar Duo Dual Action Acne Spot Treatment Cream with Benzoyl Peroxide Acne Treatment, Blemish Cream for Acne and Blackheads, Lightweight Sheerness, Safe For Sensitive Skin
  • La Roche Posay's best spot treatment for acne reduces the number and severity of acne blemishes, pimples, blackheads and whiteheads
  • Formulated with 5.5% micronized benzoyl peroxide and micro-exfoliating lipo-hydroxy acid (LHA), this acne spot treatment provides fast and visible results in less than 3 days.
  • Acne spot treatment reduces 60% of acne in 10 days with dual action that reduces the number and severity of blemishes and clears blackheads/whiteheads
  • Treats skin concerns like red, raised pimples, blackheads, whiteheads, clogged pores, and sensitive skin. Can be used as acne spot treatment or all over face.
  • Can be used as a spot treatment or all over face. Approved for ages 13 and up and safe for sensitive skin. Non drying, oil free, fast absorbing texture
SaleBestseller No. 4
Bliss Clear Genius Acne Spot Treatment | Maximum Strength 2% Salicylic Acid Shrinks Blemishes | Clean | Cruelty-Free | Paraben Free | Vegan | 0.5 oz
  • POWERFUL ACNE SPOT TREATMENT with maximum strength salicylic acid & Bliss’ CLARITY 5 Complex
  • VISIBLY SHRINKS BLEMISHES OVERNIGHT, plus reduces acne redness, size and swelling in 1 use
  • CLINICALLY PROVEN to reduce acne severity by 50% in 7 days
  • NO IRRITATION, flaking, or over-drying
  • 100% FREE FROM fragrance, alcohol, parabens, phthalates, SLS and more, plus cruelty-free, PETA-certified and vegan
Bestseller No. 5
Mighty Patch Original from Hero Cosmetics - Hydrocolloid Acne Pimple Patch for Covering Zits and Blemishes, Spot Stickers for Face and Skin, Vegan-friendly and Not Tested on Animals (36 Count)
  • 🏆 The Original Award-Winning Acne Patch: Mighty Patch is a hydrocolloid sticker that improves the look of pimples overnight without the popping. Just stick it on, get some sleep, and wake up with clearer-looking skin.
  • ⏱️ Results in 6-8 Hours: Absorbs pimple gunk thanks to our medical-grade hydrocolloid. Clinically tested, drug-free, and safe for all skin types.
  • 🛌 All-Night Adhesion: Strong enough to stay on through a whole night of tossing, turning, and pillow-squishing. Easy to remove in the AM without redness or irritation.
  • ✨ Blends Seamlessly into Skin: The thin sticker with a translucent matte finish keeps your pimple under wraps day or night. You might just forget you’re even wearing it.
  • 🕊️ Peace-Of-Mind Design: Our hydrocolloid patches are UV sterilized, and allergy tested. Each box comes with 36 medium dots (12 millimeters) on easy-peel perforated sheets.
Bestseller No. 6
Proactiv Emergency Blemish Relief - Benzoyl Peroxide Gel - Acne Spot Treatment for Face and Body, .33 Oz
  • EMERGENCY RELIEF: This invisible benzoyl peroxide spot treatment contains a powerful dose of microcrystal benzoyl peroxide to target acne-causing bacteria inside pores to clear up acne blemishes.
  • YOU NEED MORE THAN A PIMPLE CREAM: Proactiv's benzoyl peroxide acne treatment is designed to unclog pores and is specially formulated to help absorb excess oil and clear emergency blemishes fast.
  • PERFECT FOR ON THE GO: Unexpected blemishes can happen any time, so this pocket-sized spot treatment can go wherever you do.
  • SAFE FOR ALL AGES: Proactiv's acne skin care treatment provides the same powerful skin care for teens and adults.
  • MADE FOR YOUR SKIN: Proactiv Solution delivers benzoyl peroxide microcrystals deep into your pores to help stop acne-causing bacteria in its tracks and prevent new breakouts from forming.
Bestseller No. 7
Neutrogena On-The-Spot Acne Treatment, Vanishing Formula 0.75 oz (21 g)
  • Neutrogena On-the-Spot Acne Treatment, Vanishing Formula 0.75 oz (21 g)
  • Warnings For external use only. Persons sensitive to benzoyl peroxide should not use this product. If excess irritation occurs, discontinue use. Keep away from eyes, lips and mouth. This product may bleach hair or dyed fabrics. Keep this and all drugs out of reach of children. In case of accidental ingestion, seek professional assistance or contact a Poison Control Center immediately. Keep from heat.
Bestseller No. 8
Neutrogena On-The-Spot Acne Spot Treatment with 2.5% Benzoyl Peroxide Acne Treatment Medicine to Treat Face Acne, Gentle Benzoyl Peroxide Pimple Gel for Acne Prone Skin,.75 oz (Pack of 2)
  • .75-ounce tube of Neutrogena On-The-Spot Acne Treatment with benzoyl peroxide to fight acne
  • Lightweight acne treatment absorbs quickly with no burning and won't dry out skin.Oil free
  • On-The-Spot treatment is clinically proven to be so effective that skin starts getting clearer on day 1 to give long-lasting acne treatment without over-drying or burning skin.
  • The formula goes deep down into pores to kill acne bacteria that cause pimples and helps stop new ones from forming.
  • This acne treatment is formulated with 2.5% benzoyl peroxide acne medicine, to help treat and prevent acne
Bestseller No. 9
Pacifica Dry It Out Acne Gel Spot Treatment Unisex 1 oz
  • SPOT TREAT AND PREVENT ACNE with this gentle yet effective spot treatment that's designed to dry out blemishes on the spot leaving skin looking and feeling smoother
  • WITCH HAZEL AND MAXIMUM STRENGTH SALICYLIC ACID come together to help remove excess oil from the skin, unclog pores and calm the appearance of red, irritated skin
  • FORMULATED FOR ACNE PRONE AND OILY SKIN TYPES with niacinamide's anti-inflammatory properties to help reduce redness and inflammation caused by acne, rosacea, and other inflammatory skin conditions
  • DERM TESTED & SENSITIVE SKIN APPROVED* and made with ingredients we love including cucumber, sage, mint, niacinamide and salicylic acid *3rd party tested on sensitive skin with 100% reporting that it did not make their skin more sensitized
  • FREE OF HARSH CHEMICALS including parabens, phthalates and other ingredients you don't want on your skin, as well as cruelty free and 100% vegan
Bestseller No. 10
Clean & Clear PersaGel 10 Acne Medication Spot Treatment with Maximum Strength 10 Benzoyl Peroxide Topical Pimple Cream Acne Gel medication for Face Acne with Benzoyl Peroxide, 4 Count
  • Four 1-ounce tubes of Clean & Clear Persa-Gel 10 Acne Medication with 10% Benzoyl Peroxide to help effectively treat pimples and prevent future breakouts
  • Acne spot treatment gel contains 10% benzoyl peroxide and goes to work quickly by targeting the source of where breakouts begin
  • Features the same acne treatment formula prescribed by doctors for 10+ years without a prescription and provides clearer looking skin by releasing benzoyl peroxide deep down where pimples begin
  • Prescription-strength topical pimple medication goes to work quickly to treat and clear pimples, and help prevent blemishes from forming for clearer looking skin
  • Suitable for regular use in an acne skincare routine. To use, thoroughly cleanse skin, then apply a thin layer of the gel pimple cream to the affected area 1-3 times daily, if needed

Things to Consider When Buying the Best Spot Treatments for Acne

Ingredients

When it comes to choosing the best spot treatment for acne, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a spot treatment.

Price

Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best spot treatment for acne.

Avoid Harsh Chemicals

When looking for the best spot treatment for acne, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best spot treatment for acne, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best spot treatment for acne. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the spot treatment you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which spot treatment you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.

Conclusion

It can be challenging to find the best spot treatment for acne. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best spot treatment for your needs.

Which one of these spot treatments are you going to try? Let us know in the comments below. If you have any questions, ask away.

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