10 Best Serums for Wrinkles in 2022

With so many options, finding the best serum for wrinkles can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best serum for wrinkles. Let’s have a look.

Top 10 Best Serums for Wrinkles

Bestseller No. 1
RoC Derm Correxion Fill + Treat Advanced Retinol Serum, Wrinkle Filler Treatment with Hyaluronic Acid for Forehead Wrinkles, Crow's Feet, Eleven Wrinkles, and Laugh Lines, 15ml
  • WRINKLE FILLER TREATMENT: Developed with Dermatologists & Plastic Surgeons, this serum contains 3 forms of Hyaluronic Acid to instantly plump skin & fill in the look of wrinkles. Over time, pure RoC Retinol & Swertiamarin provide lasting improvements to deliver visibly smoother-looking skin. Refill available.
  • PROVEN RESULTS: In a clinical study, 97% of participants instantly had fine lines & wrinkles visibly plumped & filled - no injections needed. After 4 weeks, 100% had a visible improvement in the look of hard-to-treat wrinkles. Dermatologist tested. Fragrance-free. Paraben-free. Non-comedogenic. Phthalate-free.
  • ANTI-AGING FORMULAS: Whether you're looking for a solution for deep wrinkles, fine lines, dark circles, crow's feet, uneven skin tone or dry skin, we have an anti-aging formula that's right for you.
  • SCIENCE & BEAUTY: We produce a wide array of skin care products & treatments including daily moisturizers with SPF, hyaluronic and niacinamide acids, facial cleansers, vitamin C serums, retinol skin tone & wrinkle regimens & creams for under eyes, neck firming, decollete & much more.
  • SKIN CARE INNOVATION: Our products are recognized by beauty industry leaders & dermatologists for their best-in-class effectiveness. We continue to research & innovate new formulas for healthier skin.
SaleBestseller No. 2
TruSkin Vitamin C Serum for Face – Anti Aging Face Serum with Vitamin C, Hyaluronic Acid, Vitamin E – Brightening Serum for Dark Spots, Even Skin Tone, Eye Area, Fine Lines & Wrinkles, 1 Fl Oz
  • SKIN BRIGHTENING SERUM: Our most popular facial serum uses vitamin C to even skin tone, neutralize free radicals and boost collagen, thus improving radiance and reducing dark spots, fine lines and wrinkles
  • PLANT-BASED, SKIN-FRIENDLY FORMULATIONS: Our anti aging serum is a purposefully balanced blend for skin nutrition, harnessing support from botanical hyaluronic acid, vitamin E, aloe vera, jojoba oil and MSM to help brighten, calm and protect skin
  • PURE & POTENT SKIN CARE: Vegan and cruelty-free skin nourishment using antioxidants, nutrients and botanical actives to improve skin wellness, all in a fragrance free formula without parabens and other harmful chemicals you don’t want
  • DIRECTIONS: TruSkin Vitamin C Serum for face with hyaluronic acid can be used morning and/or night. Apply 3-5 drops of serum to clean fingertips, palm or back of hand and use fingertips to gently smooth onto face and under eyes
  • EXTENDED MANUFACTURER GUARANTEE: Love it or your money back! If for any reason you decide this product isn't a fit for your skin, we offer a 90-day money-back refund. The expiration date is printed on the barcode sticker attached to the packaging
SaleBestseller No. 3
RoC Retinol Correxion Deep Wrinkle Retinol Face Serum with Ascorbic Acid, Daily Anti-Aging Skin Care Treatment for Fine Lines, Dark Spots, Acne Scars, 1 Ounce (Packaging May Vary)
  • ANTI-WRINKLE SERUM TREATMENT: Made with pure RoC Retinol and RoC's exclusive mineral complex for additional hydration & enhanced Retinol efficacy, this serum works to complement skin’s renewal process and bring fresher, revitalized-looking skin to the surface. The longer you use it - the more dramatic age-defying results you will see. Gentle enough for daily use by men and women.
  • PROVEN RESULTS: With daily use, this serum is clinically proven to help deliver smoother, more radiant skin in 4 weeks & diminish the look of photodamage in 8 weeks. Deep wrinkles, even those that are deep-set appear visibly reduced. Non-greasy. Non-comedogenic. Dermatologist-tested. Paraben-Free.
  • ANTI-AGING FORMULAS: Whether you're looking for a solution for deep wrinkles, fine lines, dark circles, crow's feet, uneven skin tone or dry skin, we have an anti-aging formula that's right for you.
  • SCIENCE & BEAUTY: We produce a wide array of skin care products & treatments including daily moisturizers with SPF, hyaluronic and niacinamide acids, facial cleansers, vitamin C serums, retinol skin tone & wrinkle regimens & creams for under eyes, neck firming, decollete & much more.
  • SKIN CARE INNOVATION: Our products are recognized by beauty industry leaders & dermatologists for their best-in-class effectiveness. We continue to research & innovate new formulas for healthier skin.
SaleBestseller No. 4
PURE Vitamin C Serum for Face, 20% Vit C Serum WITH HYALURONIC ACID+RETINOL+FERULIC ACID+VIT E-Anti Aging Serum for Glowing Skin-Skin Brightening Serum-Antioxidant Serum-Reduce Wrinkles & Dark Spots
  • VITAMIN C IN ITS MOST STABLE FORM: Most brands formulate vitamin C serums with ascorbic acid, which is too unstable to be effective. We use THE MOST POTENT PURE VITAMIN C, sodium ascorbyl phosphate. In a study of 47 users, 94% said dark spots had faded, and 91% saw more radiance in just 2 weeks.
  • SCIENTIFICALLY OPTIMAL 20% CONCENTRATION: Many serums either contain too little (<15%) or too much (22%+) vitamin C. Our skin brightening serum has an optimal 20% concentration. It RESURFACES & REJUVENATES WITHOUT DRYING SKIN. Higher concentrations can be irritating, especially on sensitive skin.
  • 6X FASTER RESULTS WITH C-BOOST: Our anti aging serum with 5 SYNERGISTIC INGREDIENTS – retinol, jojoba oil, vitamin E, aloe vera & MSM – DOUBLES VITAMIN C’S PHOTOPROTECTIVE QUALITIES. It also accelerates skin renewal and new cell turnover, so you see results 6x faster than with vitamin C alone.
  • COLD PROCESSED FOR 4X MORE STABILITY: Other serums are produced at 90°C, which depletes 31% of vitamin C’s antioxidant activity in 48 hours. For FULL POTENCY PRESERVATION, our antioxidant serum is COLD PROCESSED at 1-4°C, then packaged in FrostProtect glass that blocks destabilising light & oxygen.
  • DERMATOLOGIST-DEVELOPED FORMULA: Instead of synthetics, our pure vit C serum features vitamin C from Floridian oranges. Our brightening face serum is VEGAN & CRUELTY FREE, and is made without parabens & silicones. 92% of users surveyed would repurchase it to TACKLE DARK SPOTS, FINE LINES & BREAKOUTS.
SaleBestseller No. 5
Neutrogena Rapid Wrinkle Repair 0.3% Concentrated Retinol Face Oil, Daily Anti-Aging Face Serum to Fight Fine Lines, Deep Wrinkles, & Dark Spots, 1.0 fl. oz
  • This product is non-sealed
  • 1.0-fluid ounces of Neutrogena Rapid Wrinkle Repair Retinol Anti-Wrinkle Oil Serum to nourish and reduce the look of deep wrinkles
  • This super concentrated, lightweight facial oil intensely nourishes to fight deep, stubborn wrinkles. It is formulated with retinol, a dermatologist-proven form of vitamin A, to fight fine lines dullness, wrinkles and dark spots
  • Anti-Wrinkle treatment made with retinol, has been dermatologist tested and is suitable for daily use for all skin tones
  • The perfect addition to a daily skincare routine, this anti-wrinkle retinol serum is fast absorbing and is clinically proven to reduce the appearance of stubborn and deep wrinkles, and intensely nourish and renew the look of skin
  • Oil is formulated with pure 0.3% retinol which is scientifically proven superior to commonly used retinyl esters. The face oil is formulate without parabens, mineral oil and dyes and comes from the #1 retinol brand used most by dermatologists
SaleBestseller No. 6
CeraVe Anti Aging Retinol Serum | Cream Serum for Smoothing Fine Lines and Skin Brightening | With Retinol, Hyaluronic Acid, Niacinamide, and Ceramides | 1 Ounce
  • [ RETINOL SERUM FOR FACE ] Anti-aging facial serum with Retinol to help improve skin’s texture including visible signs of aging for more radiant skin and Hyaluronic Acid to help retain skin’s natural moisture, and Niacinamide to help calm skin.
  • [ SMOOTH TEXTURE ] Lightweight serum with a gel texture and a non-greasy feel. If layering with an eye cream or facial moisturizer, apply Skin Renew Retinol Serum in a thin layer and allow to fully absorb into skin before applying additional products.
  • [ GENTLE ON SKIN ] Fragrance free, non-comedogenic, and non-irritating formula. As retinol can cause sun sensitivity, please apply Skin Renewing Retinol Serum at night or wear a facial moisturizer with at least SPF 30 sunscreen if wearing during the day.
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.
SaleBestseller No. 7
L’Oreal Paris 1.5% Pure Hyaluronic Acid Serum for Face with Vitamin C from Revitalift Derm Intensives for Dewy Looking Skin, Hydrate, Moisturize, Plump Skin, Reduce Wrinkles, Anti Aging Serum, 1 Oz
  • Intensive hydrating 1.5 percent Pure Hyaluronic Acid Serum for face with Vitamin C moisturizes skin instantly for dewy glow and visibly plumped skin; Reduces wrinkles and boosts skin's radiance; Effective for all skin tones
  • Instant relief for dry skin; This hyaluronic acid moisturizer for face deeply hydrates skin immediately; In 1 week, visibly plumps for younger looking skin that feels firmer, more elastic and radiant; Skin looks and feels dewy instantly and overtime
  • Hyaluronic Acid (HA) is a potent hydration-attracting molecule naturally found in the skin; This formulation combines low-molecular and high-molecular weight for multi-depth hydration; Vitamin C is a vital antioxidant known to boost skin's radiance
  • Lightweight gel serum absorbs fast with no tacky feel or leftover residue; Sheer finish on skin and wears well under makeup as a primer; for a dewy boost of hydration; #1 Serum in The World *Based on NielsenIQ RMS data. 12M Period Ending August 2022
  • Hyaluronic Acid Serum with Vitamin C for face and neck; Fragrance free, paraben free, mineral oil free, no synthetic dyes; Dermatologist tested; Suitable for every skin type: dry skin, oily skin, combination skin, sensitive skin and mature skin
Bestseller No. 8
Plexaderm Rapid Reduction Eye Serum - Advanced Formula - Anti Aging Serum Visibly Reduces Under-Eye Bags, Wrinkles, Dark Circles, Fine Lines & Crow's Feet Instantly - Instant Wrinkle Remover for Face
  • ANTI-AGING ADVANCED GOODNESS – Plexaderm Rapid Reduction Serum harnesses the power of silicate minerals derived from shale clay to create a temporary skin tightening layer on your skin that lifts, tightens and smooths the skin for a more youthful appearance.
  • SMOOTHER THAN EVER – Our facial serum was formulated to be easier to spread and more evenly applied than previous formulas. It has a smoother feeling when dry and a more satin finish, leaving you with a natural youthful glow.
  • AT HOME INSTANT FACE LIFT – Our clinically tested anti wrinkle repair formula gives instant results in as little as 10 minutes that leave you looking years younger. Get immediate results without turning to expensive cosmetic treatments that can be painful and time consuming!
  • 10 HOURS OF ONGOING BEAUTY – Our advanced skin serum was clinically tested and shows that results can last for up to 10 hours. Apply to clean and dry skin. Allow Plexaderm Rapid Reduction Serum to set and dry for 10 minutes after application. Avoid moving the areas in which you’ve applied Plexaderm so that you can achieve optimal results.
  • PERFECT FOR ALL – Plexaderm goes on clear so nobody will know you are using it and it is easy to apply! This anti-aging serum has both men and women nationwide happy with their youthful-looking skin and younger appearance.
Bestseller No. 9
Collagen Peptide Serum - Best Anti Aging Collagen Serum for Face, Skin Brightening, Reduces Fine Lines & Wrinkles, Heals, and Repairs Skin, Microneedling Serum with Aloe Vera & Hyaluronic Acid - Peptide Complex Face Serum by Eva Naturals (2 oz)
  • POWER OF PEPTIDES - Peptides are anti-aging proteins that alert skin when it's time to produce more collagen in order to smooth away wrinkles and improve elasticity for a stunningly youthful glow.
  • ANTI WRINKLE SERUM - Our skin serum can plump face, skin, and lips. When skin is firmer and plumper, wrinkles and fine lines will be less visible. Peptides are known for being rich in antioxidants that fight free radicals, keeping your skin youthful.
  • SMOOTH AND HYDRATE - Achieving a softer, firmer complexion is easier than you think. Along with amino acids and peptides this facial serum uses hyaluronic acid, hazel and jojoba to help hydrate and even the skin.
  • EFFECTIVE DARK SPOT REMOVER - The stimulation of collagen and elastin fibroblasts has the added benefit of acting as a dark spot corrector penetrating deeply into the skin to remove dark spots, age spots, freckles, and sun spots to give you an even skin tone.
  • TRUSTED NAME - Eva Naturals has quickly become one of the most trusted names in plant-based skincare. Our anti aging serum is Cruelty Free and is safe for all skin types!
SaleBestseller No. 10
Neutrogena Rapid Wrinkle Repair Retinol Face Serum, Daily Anti-Aging Serum for Face with Retinol & Hyaluronic Acid to Fight Fine Lines, Wrinkles, & Dark Spots, 1 fl. oz
  • Lightweight, silky facial serum contains the powerhouse ingredient retinol, a dermatologist-proven form of vitamin A, to fight fine lines, dullness, wrinkles and dark spots
  • It instantly softens and smooths skin and improves the look of wrinkles and dark spots
  • Face serum with retinol is suitable for daily use for all skin tones. The retinol serum is formulated to be free of mineral oil and dyes
  • The perfect addition to a daily at-home anti-age skincare routine, this anti-wrinkle retinol serum is proven to work quickly and is the #1 retinol brand used most by dermatologists
  • Accelerated retinol-SA
  • Smoothes fine lines and texture
  • Fades the look of stubborn wrinkles

Things to Consider When Buying the Best Serums for Wrinkles

Ingredients

When it comes to choosing the best serum for wrinkles, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a serum.

Price

Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best serum for wrinkles.

Avoid Harsh Chemicals

When looking for the best serum for wrinkles, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best serum for wrinkles, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best serum for wrinkles. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the serum you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which serum you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.

Conclusion

It can be challenging to find the best serum for wrinkles. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best serum for your needs.

Which one of these serums are you going to try? Let us know in the comments below. If you have any questions, ask away.

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