10 Best Drugstore Serum for Dark Spots in 2022

With so many options, finding the best drugstore serum for dark spots can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best drugstore serum for dark spots. Let’s have a look.

Top 10 Best Drugstore Serum for Dark Spots

SaleBestseller No. 1
TruSkin Vitamin C Serum for Face – Anti Aging Face Serum with Vitamin C, Hyaluronic Acid, Vitamin E – Brightening Serum for Dark Spots, Even Skin Tone, Eye Area, Fine Lines & Wrinkles, 1 Fl Oz
  • SKIN BRIGHTENING SERUM: Our most popular facial serum uses vitamin C to even skin tone, neutralize free radicals and boost collagen, thus improving radiance and reducing dark spots, fine lines and wrinkles
  • PLANT-BASED, SKIN-FRIENDLY FORMULATIONS: Our anti aging serum is a purposefully balanced blend for skin nutrition, harnessing support from botanical hyaluronic acid, vitamin E, aloe vera, jojoba oil and MSM to help brighten, calm and protect skin
  • PURE & POTENT SKIN CARE: Vegan and cruelty-free skin nourishment using antioxidants, nutrients and botanical actives to improve skin wellness, all in a fragrance free formula without parabens and other harmful chemicals you don’t want
  • DIRECTIONS: TruSkin Vitamin C Serum for face with hyaluronic acid can be used morning and/or night. Apply 3-5 drops of serum to clean fingertips, palm or back of hand and use fingertips to gently smooth onto face and under eyes
  • EXTENDED MANUFACTURER GUARANTEE: Love it or your money back! If for any reason you decide this product isn't a fit for your skin, we offer a 90-day money-back refund. The expiration date is printed on the barcode sticker attached to the packaging
Bestseller No. 2
Paulas Choice--SKIN PERFECTING 2% BHA Liquid Salicylic Acid Exfoliant--Facial Exfoliant for Blackheads, Enlarged Pores, Wrinkles & Fine Lines, 4 oz Bottle
  • GENTLE NON-ABRASIVE LEAVE-ON EXFOLIATOR: with 2% BHA (Beta hydroxy acid) to unclog & diminish enlarged pores, exfoliate dead skin cells, smooth wrinkles & brighten & even out skin tone. Combats redness, wrinkles, aging, enlarged pores, & blackheads. PACKAGING MAY VARY.
  • Dramatically improves skin's texture for radiant youthful even-toned skin. Beta hydroxy acid (BHA also known as salicylic acid) mimics the natural exfoliation process of younger skin by helping it shed extra layers while unclogging and clearing pores.
  • HYDRATE, BRIGHTEN & SMOOTH FINE LINES: Our unique, non-abrasive, leave-on exfoliant is gentle enough for daily use on all skin types. Exfoliates dead skin cells while clearing pores for a more even tone, plus it visibly reduces fine lines & wrinkles.
  • Paula's Choice facial exfoliants are gentler on delicate skin of the face & neck than an abrasive face scrub, which can cause micro-tears. A BHA leave-on exfoliator delivers hydration & can exfoliate directly inside the pore & improve how the pore works.
  • Paula's Choice Skincare makes products that work. No fragrance, no parabens, no fluff. Just effective, science-backed formulas that target any concern from wrinkles to breakouts.
SaleBestseller No. 3
Dark Spot Correcting Face Serum by the makers of Differin Gel, Dark Spot Correcting Serum, Gentle Skin Care for Acne Prone Sensitive Skin, 1 oz (Packaging May Vary)
  • Differin Dark Spot Correcting Serum features 4% Niacinamide, a brightening ingredient that's clinically proven to reduce the appearance of dark spots and discoloration
  • Gel-like formula goes on smoothly invisibly under makeup
  • With antioxidant sea buckthorn berry oil to help soothe skin and citric acid to help renew the skin's surface
  • Paraben Free, Non Comedogenic, Dermatologist Tested, and gentle enough for daily use
  • Improves luminosity
SaleBestseller No. 4
Eva Naturals Vitamin C Serum for Face Plus Hyaluronic Acid, Retinol, Niacinamide & Salicylic Acid, Anti Aging Serum, Reduce Fine Lines, Wrinkles & Dark Spots, Brightening Skin Serum for Glowing Skin (1 oz)
  • BEST ANTI AGING SERUM - Loaded with antioxidants, our Vitamin C Serum for face with hyaluronic acid helps boost collagen production and reduce fine lines and wrinkles! Hyaluronic Acid provides incredible hydration by holding up to 1000 times its weight in water!
  • GLOWING COMPLEXION - Acne and other skin conditions leave your complexion looking red and uneven. The Niacinamide and Retinol serum found in our formula supports healthy skin by naturally reducing inflammation, correcting dark spots, and soothing troubled skin.
  • BEST ACNE TREATMENT - When pores are clogged with dirt and oil, they become larger and more visible. Retinol works to cleanse the pores, thereby making them appear smaller. Add to that the exfoliating effects of Salicylic Acid, and our face serum is ready to fight blemishes and improve acne prone skin.
  • DARK SPOT CORRECTOR - Our Vitamin C Serum face serum is crafted to attack the most important skin issues like wrinkles, fine lines, dry skin, acne, or uneven skin. Loaded with natural ingredients, this antioxidant serum can tackle any problem you have while diminishing dark spots.
  • SATISFACTION GUARANTEE - With so many skincare products promising amazing results, it’s hard to know which brands you can trust. We’re so confident that you’ll love our skin serum, we’re offering a 90-day money-back refund. You can try it risk free today!
SaleBestseller No. 5
PURE Vitamin C Serum for Face, 20% Vit C Serum WITH HYALURONIC ACID+RETINOL+FERULIC ACID+VIT E-Anti Aging Serum for Glowing Skin-Skin Brightening Serum-Antioxidant Serum-Reduce Wrinkles & Dark Spots
  • VITAMIN C IN ITS MOST STABLE FORM: Most brands formulate vitamin C serums with ascorbic acid, which is too unstable to be effective. We use THE MOST POTENT PURE VITAMIN C, sodium ascorbyl phosphate. In a study of 47 users, 94% said dark spots had faded, and 91% saw more radiance in just 2 weeks.
  • SCIENTIFICALLY OPTIMAL 20% CONCENTRATION: Many serums either contain too little (<15%) or too much (22%+) vitamin C. Our skin brightening serum has an optimal 20% concentration. It RESURFACES & REJUVENATES WITHOUT DRYING SKIN. Higher concentrations can be irritating, especially on sensitive skin.
  • 6X FASTER RESULTS WITH C-BOOST: Our anti aging serum with 5 SYNERGISTIC INGREDIENTS – retinol, jojoba oil, vitamin E, aloe vera & MSM – DOUBLES VITAMIN C’S PHOTOPROTECTIVE QUALITIES. It also accelerates skin renewal and new cell turnover, so you see results 6x faster than with vitamin C alone.
  • COLD PROCESSED FOR 4X MORE STABILITY: Other serums are produced at 90°C, which depletes 31% of vitamin C’s antioxidant activity in 48 hours. For FULL POTENCY PRESERVATION, our antioxidant serum is COLD PROCESSED at 1-4°C, then packaged in FrostProtect glass that blocks destabilising light & oxygen.
  • DERMATOLOGIST-DEVELOPED FORMULA: Instead of synthetics, our pure vit C serum features vitamin C from Floridian oranges. Our brightening face serum is VEGAN & CRUELTY FREE, and is made without parabens & silicones. 92% of users surveyed would repurchase it to TACKLE DARK SPOTS, FINE LINES & BREAKOUTS.
SaleBestseller No. 6
Neutrogena Rapid Tone Repair Retinol + Vitamin C Dark Spot Corrector Face Serum, Daily Anti-Wrinkle Retinol Dark Spot Corrector to Brighten & Even Tone, Mineral-Oil & Dye-Free, 1 oz
  • 1-fluid ounce tube of Neutrogena Rapid Tone Repair Retinol + Vitamin C Dark Spot Corrector Daily Face Serum with a dermatologist-proven retinol and Vitamin C to target stubborn dark spots for more even skin tone
  • Dark spot corrector works to renew the look of skin, by helping to brighten skin tone while improving the look of stubborn dark spots and skin discoloration
  • Clinically-proven to reduce the look of stubborn dark spots and discoloration, brighten skin tone and smooth the look of fine lines and texture. The dark spot corrector is suitable for daily use and is free of mineral oil and dyes
  • Daily facial serum formulated with pure retinol, a dermatologist-proven form of vitamin A to fight fine lines, dullness, wrinkles and dark spots, and vitamin C, to help diffuse the look of dark spots and discoloration
  • For all skin tones and suitable for daily use in a regular skin care routine, the brightening serum comes from the #1 retinol brand used by most dermatologists
Bestseller No. 7
Murad Rapid Dark Spot Corrector - Environmental Shield Skin Brightening Face Serum - Glycolic Acid Hyperpigmentation Treatment Backed by Science
  • DARK SPOT SERUM: This dark spot corrector for face and neck effectively removes existing dark spots, plus the dark spot pigment lightening formula also helps prevent dark spots you can’t yet see.
  • BRIGHTENS & REJUVENATES: Exfoliating away dull skin, the soothing facial serum promotes surface cell turnover leaving facial skin looking brighter, more even and naturally radiant.
  • DAILY SKIN TREATMENT: This dark spot serum is suitable for use on Normal, Dry, Oily, and Combination skin types, and the skin lightening serum formulation can be used daily on a range of skin tones.
  • ESSENTIAL INGREDIENTS: Patented Resorcinol reduces the intensity of dark spots, while Tranexamic Acid and Glycolic Acid exfoliate and brighten. Formulated without Parabens, Sulfates or Phthalates.
  • HOW TO USE : After cleansing, apply a thin layer of dark spot remover serum to the entire face, both morning and night. Follow with SPF Moisturizer during the day, and Detox Moisturizer at night.
SaleBestseller No. 8
CeraVe Vitamin C Serum with Hyaluronic Acid | Skin Brightening Serum for Face with 10% Pure Vitamin C | Fragrance Free | 1 Fl. Oz
  • [ ANTIOXIDANT BENEFITS ] Formulated with 10 percent l-ascorbic acid, the purest form of vitamin C, to help brighten the complexion and promote more even skin tone. Protective packaging helps prevent oxidation and maintain product performance.
  • [ HYDRATING SERUM ] Formulated with Hyaluronic Acid to help improve skin tone, texture, and hydration for a healthy looking, radiant complexion.
  • [ LIGHTWEIGHT TEXTURE ] This serum for face has a gel texture with a non-greasy feel. If layering with an eye cream or facial moisturizer, apply CeraVe Vitamin C Serum in a thin layer and allow to fully absorb into skin before applying additional products
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides make up 50% of the lipids in the skin barrier. As you age, studies show that ceramide levels decrease. CeraVe products are formulated with 3 essential ceramides (1,3,6-II) to help restore and maintain the skin barrier.
  • [ DERMATOLOGIST RECOMMENDED ] This formula is fragrance free, paraben-free, non-comedogenic, and allergy tested. CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.
SaleBestseller No. 9
RoC Multi Correxion Revive + Glow 10% Active Vitamin C Serum for Face, Daily Anti-Aging Wrinkle and Skin Tone Skin Care Treatment, Brightening Serum for Dark Spots, 1 Fluid Ounce
  • MULTI-TASKING GLOW SERUM: Reveal visibly smoother luminous skin with our lightweight Vitamin C Serum. Supercharged with a 10% active Vitamin C Blend & energizing nonapeptides to make tired, dull skin look glowing & tight + combat visible effects of environmental stressors.
  • PROVEN RESULTS: Experience clinically proven benefits. Instantly, skin is visibly radiant. In 1 week, skin looks brighter & texture is visibly improved. In 4 weeks, skin appears tighter, discoloration is visibly reduced, & elasticity appears restored.
  • ANTI-AGING FORMULAS: Whether you're looking for a solution for deep wrinkles, fine lines, dark circles, crow's feet, uneven skin tone or dry skin, we have an anti-aging formula that's right for you.
  • SCIENCE & BEAUTY: We produce a wide array of skin care products & treatments including daily moisturizers with SPF, hyaluronic and niacinamide acids, facial cleansers, vitamin C serums, retinol skin tone & wrinkle regimens & creams for under eyes, neck firming, decollete & much more.
  • SKIN CARE INNOVATION: Our products are recognized by beauty industry leaders & dermatologists for their best-in-class effectiveness. We continue to research & innovate new formulas for healthier skin.
SaleBestseller No. 10
IT Cosmetics Bye Bye Dark Spots 4% Niacinamide Serum - Visibly Reduces Dark Spots & Improves Skin Clarity In 8 Weeks - With 1% Ethyl Vitamin C - For All Skin Types - 1 fl oz
  • BYE BYE DARK SPOTS - This hyperpigmentation serum is your secret weapon to fight skin discoloration. Formulated with 4% niacinamide and 1% ethyl vitamin C, it helps visibly reduce dark spots and improve skin clarity in just 8 weeks!
  • KEY INGREDIENTS - While pure vitamin C & niacinamide are two powerful, tone-evening, discoloration-fighting molecules, they cannot be formulated together in one product. Instead, we use a highly stable, bioavailable vitamin C derivative.
  • SKIN-LOVING FORMULA - IT Cosmetics Bye Bye Dark Spots Niacinamide Serum is your solution for age spots, melasma, and other types of discoloration. Our dermatologist-tested treatment is suitable for all skin types, even the most sensitive.
  • HOW TO APPLY - After cleansing in the AM & PM, apply 4-5 drops onto clean skin, using fingertips. Press serum into entire face and neck, avoiding eye area. Follow with Confidence in a Gel Lotion Moisturizer and, in the AM, CC+ Cream with SPF 50+.
  • IT REALLY WORKS - With clinical insights from plastic surgeons, plus ingredient and skincare expertise from dermatologists, IT Cosmetics creates problem-solving products that give you real results!

Things to Consider When Buying the Best Drugstore Serum for Dark Spots

Ingredients

When it comes to choosing the best drugstore serum for dark spots, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a drugstore serum.

Price

Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best drugstore serum for dark spots.

Avoid Harsh Chemicals

When looking for the best drugstore serum for dark spots, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best drugstore serum for dark spots, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best drugstore serum for dark spots. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the drugstore serum you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which drugstore serum you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.

Conclusion

It can be challenging to find the best drugstore serum for dark spots. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best drugstore serum for your needs.

Which one of these drugstore serums are you going to try? Let us know in the comments below. If you have any questions, ask away.

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