10 Best Drugstore Night Creams for Acne Prone Skin in 2022

With so many options, finding the best drugstore night cream for acne prone skin can be overwhelming. There are so many things to consider such as ingredients, formula, brand name, price, and so much more. Needless to say, this can be pretty time-consuming.

To save you the hassle, we researched hundreds of products and sifted through thousands of customer reviews. Then we checked the ingredients, formula, efficacy, and price. Based on this, we bring you the best drugstore night cream for acne prone skin. Let’s have a look.

Top 10 Best Drugstore Night Creams for Acne Prone Skin

SaleBestseller No. 1
Night Cream with Hyaluronic Acid by the Makers of Differin Gel, Restorative Night Moisturizer, Gentle Skin Care for Acne Prone Sensitive Skin, 2.5 Oz (Packaging May Vary)
  • Hydrating formula with hyaluronic acid, ceramides, and allantoin to visibly improve skin texture by hydrating dry skin overnight
  • Hyaluronic acid is naturally found in skin and binds to water to help retain natural moisture and keep skin looking plump
  • Ceramides help maintain and restore the skin barrier to lock in moisture for a full 24 hours
  • Allantoin soothes dry, flaky skin
  • Dermatologist developed and tested formula that is non irritating, fragrance free, and non comedogenic
SaleBestseller No. 2
CeraVe Skin Renewing Night Cream | Niacinamide, Peptide Complex, and Hyaluronic Acid Moisturizer for Face | 1.7 Ounce, Packaging may Vary
  • [ PEPTIDE COMPLEX ] Help reduced the look of fine lines and wrinkles while supporting skin elasticity
  • [ OVERNIGHT MOISTURIZER ] Helps soften, hydrate and retain skin's moisture with hyaluronic acid. Renew the look of tired skin overnight. This skin care product does not come with a protection inner seal.
  • [ GENTLE ON SKIN ] Fragrance free, non-comedogenic, and non-irritating formula
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.
Bestseller No. 3
La Roche-Posay Toleriane Double Repair Face Moisturizer, Daily Moisturizer Face Cream with Ceramide and Niacinamide for All Skin Types, Oil Free, Fragrance Free
  • Toleriane Double Repair Face Moisturizer is formulated with dermatologist-recommended ingredients including ceramide-3, niacinamide, glycerin and La Roche-Posay Prebiotic Thermal Water
  • Double action helps repair skin’s natural protective barrier after 1-hour and provide up to 48-hour hydration. Produces a unique prebiotic action on the skin microbiome and restores healthy-looking skin
  • Its lightweight cream texture easily absorbs into the skin to provide immediate comfort
  • Suitable for all skin types, including sensitive. Fragrance free, paraben free, oil free, alcohol free, non comedogenic
  • Formulated with Ceramide-3: to help retain moisture and maintain a healthy skin barrier. Niacinamide: helps restore skin's moisture barrier, and visibly fading skin discolorations. Glycerin: hydrates skin
Bestseller No. 4
[CRAZY SKIN] Skin Repair Trouble Care Sleeping Cream 1.76oz | Deep Moisturizing pH level 5.5 overnight cream | Moisturizer for acne prone skin | Korean skin care | night cream sleeping mask recovery care
  • 🌙 Lupeol(eggplant extract) : moisturizes & supports skin without worrying about irritating your delicate condition.
  • 🌙 Salicylic acid: helps to unclog pores and gently exfoliates skin, which is best for acne prone skin
  • 🌙 Hydrate, Brighten & Smooth: Seven plants, herbal extracts, and aloe help to quench thirsty skin and renew your skin, by strengthening the skin barrier
  • 🌙 Calms down & Rejuvenate your sensitive skin: Mild ph acid 5.5(5.3~5.9) overnight cream is suitable for breakout-prone skin.
  • 🌙 Essence formula: absorbs instantly without feeling greasy 🎁 Perfect Gift Options are available for your convenience!
Bestseller No. 5
Paulas Choice--SKIN PERFECTING 2% BHA Liquid Salicylic Acid Exfoliant--Facial Exfoliant for Blackheads, Enlarged Pores, Wrinkles & Fine Lines, 4 oz Bottle
  • GENTLE NON-ABRASIVE LEAVE-ON EXFOLIATOR: with 2% BHA (Beta hydroxy acid) to unclog & diminish enlarged pores, exfoliate dead skin cells, smooth wrinkles & brighten & even out skin tone. Combats redness, wrinkles, aging, enlarged pores, & blackheads. PACKAGING MAY VARY.
  • Dramatically improves skin's texture for radiant youthful even-toned skin. Beta hydroxy acid (BHA also known as salicylic acid) mimics the natural exfoliation process of younger skin by helping it shed extra layers while unclogging and clearing pores.
  • HYDRATE, BRIGHTEN & SMOOTH FINE LINES: Our unique, non-abrasive, leave-on exfoliant is gentle enough for daily use on all skin types. Exfoliates dead skin cells while clearing pores for a more even tone, plus it visibly reduces fine lines & wrinkles.
  • Paula's Choice facial exfoliants are gentler on delicate skin of the face & neck than an abrasive face scrub, which can cause micro-tears. A BHA leave-on exfoliator delivers hydration & can exfoliate directly inside the pore & improve how the pore works.
  • Paula's Choice Skincare makes products that work. No fragrance, no parabens, no fluff. Just effective, science-backed formulas that target any concern from wrinkles to breakouts.
Bestseller No. 6
Acne Wipeout Time-Released Retinol Plus - Skin Smoothing Night Face Cream with Retinol. Natural Retinoid. Unclogs Pores and Smooths Skin All Night and Minimizes Dryness and Irritation, 1 fl oz
  • The Smoothing Power of Retinol Without the Harshness: Time-Released smoothing lotion with Retinol Plus works all night to unclog pores and smooth acne-prone skin. This retinol treatment minimizes irritation and provides maximum results
  • Night Cream for Acne Prone Skin: Acne Wipeout Time-Released Retinol Plus Skin Smoothing Night Face Cream is formulated as a natural retinoid. Our Retinol Plus treatment works all night to unclog pores, an essential part of Combination Therapy which is the acne-clearing regimen most recommended by dermatologists
  • Perfect Pair Combination Therapy Acne Treatment: Acne Wipeout Time-Released Retinol Plus Night Cream is perfectly paired with Acne Wipeout Breakout Control acne cream. Topical retinol and benzoyl peroxide work together to target both inflammatory and comedonal acne, including maskne, to effectively clear and control acne
  • Your Nightly Super Skin Smoothing Cream: Use Acne Wipeout Time-Released Retinol Plus Night Face Cream every evening (Use in combination with All Day Breakout Control to fight acne all day). Apply Retinol Plus to your face, avoiding the eye area. Do not rinse. Limit sun exposure during the day and always use sunscreen when going outdoors
  • Skin-Friendly and Skin-Safe Treatment: Time-released, encapsulated technology minimizes skin irritation, redness, and dryness while smoothing skin and unclogging pores. Our topical retinol treatment is non-comedogenic, fragrance-free, paraben-free and sulfate-free
SaleBestseller No. 7
Honest Beauty Hydrogel Cream with Two Types of Hyaluronic Acid & Squalane OilFree, Synthetic, Dermatologist Tested, Cruelty Free, Fragrance Free, 1.7 Fl Oz
  • New look, same great formula; packaging may vary
  • 2019 Byrdie Skincare Awards
  • Hyaluronic Acid infused face cream
  • Helps soften & firm skin
  • Refreshes & cools on application; Dermatologist tested, Cruelty Free plus Vegan; EWG Certified; 100% tree-free paper carton
SaleBestseller No. 8
TruSkin Vitamin C Serum for Face – Anti Aging Face Serum with Vitamin C, Hyaluronic Acid, Vitamin E – Brightening Serum for Dark Spots, Even Skin Tone, Eye Area, Fine Lines & Wrinkles, 1 Fl Oz
  • SKIN BRIGHTENING SERUM: Our most popular facial serum uses vitamin C to even skin tone, neutralize free radicals and boost collagen, thus improving radiance and reducing dark spots, fine lines and wrinkles
  • PLANT-BASED, SKIN-FRIENDLY FORMULATIONS: Our anti aging serum is a purposefully balanced blend for skin nutrition, harnessing support from botanical hyaluronic acid, vitamin E, aloe vera, jojoba oil and MSM to help brighten, calm and protect skin
  • PURE & POTENT SKIN CARE: Vegan and cruelty-free skin nourishment using antioxidants, nutrients and botanical actives to improve skin wellness, all in a fragrance free formula without parabens and other harmful chemicals you don’t want
  • DIRECTIONS: TruSkin Vitamin C Serum for face with hyaluronic acid can be used morning and/or night. Apply 3-5 drops of serum to clean fingertips, palm or back of hand and use fingertips to gently smooth onto face and under eyes
  • EXTENDED MANUFACTURER GUARANTEE: Love it or your money back! If for any reason you decide this product isn't a fit for your skin, we offer a 90-day money-back refund. The expiration date is printed on the barcode sticker attached to the packaging
Bestseller No. 9
Plum Skin Renewing Night Face Gel with Green Tea & Glycolic Acid for Oily & Acne Prone Skin, Hydrating Moisturizer for Dry Skin, Gentle for Sensitive Skin, Paraben & Cruelty Free for Women,1.69 Fl OZ
  • The ultra-light Plum Green Tea Night Gel with glycolic acid ensures no more oily mornings. It is a night gel with an ultra-light gel texture that is pillow-proof and leaves your skin non-greasy and fresh the next morning. It is best suited for oily and acne-prone skin.
  • This night gel contains non-comedogenic ingredients. Glycolic acid sweeps away skin debris and prepares the skin for self-renewal. It works wonders with all your pigmentation issues. Our goodness chemists know exactly what's required to do the job without overdoing it.
  • Argan oil provides balanced hydration and helps skin retain moisture overnight, leaving your skin fresh and nourished. Rich in essential fatty acids, or EFAs, which support the health and beauty of the skin and hair it is the perfect ingredient for regulating sebum production to keep the skin’s natural oils at a healthy level. It can help to treat several different types of acne and promotes a smoother, calmer complexion.
  • Antioxidant Green tea extracts help combat acne and have a concentrated source of polyphenols and other antioxidants, to stop the acne formation cycle in its tracks. Oxidation of skin-produced sebum is a key step in acne formation – something we are looking to stop here. In doing so it leaves behind brighter and glowing skin!
  • Plum Renewed Clarity Night Gel, Green Tea is 100% vegan. This moisturizing night gel is paraben-free, phthalate-free, and cruelty-free as always. It works on oily, acne-prone, and combination skin for overnight repairs.
Bestseller No. 10
CeraVe PM Facial Moisturizing Lotion | Night Cream with Hyaluronic Acid and Niacinamide | Ultra-Lightweight, Oil-Free Moisturizer for Face | 3 Ounce
  • This product is non-sealed
  • [ OIL FREE NIGHT LOTION ] Use Cerave PM facial lotion as the last step in an evening skincare routine. If layering with an eye cream, moisturizer or facial serum, apply the Cerave night lotion after other product applications have been fully absorbed
  • [ OVERNIGHT MOISTURIZER ] Cerave’s PM face cream contains niacinamide to help calm the skin and uses MVE Technology to deliver hydration throughout the night. It also contains hyaluronic acid to help retain skin's moisture
  • [ GENTLE ON SKIN ] Fragrance free, paraben-free, oil free, non-comedogenic, and allergy-tested
  • [ 3 ESSENTIAL CERAMIDES ] Ceramides are found naturally in the skin and make up 50% of the lipids in the skin barrier. All CeraVe products are formulated with three essential ceramides (1, 3, 6-II) to help restore and maintain the skin’s natural barrier
  • [ DEVELOPED WITH DERMATOLOGISTS ] CeraVe Skincare is developed with dermatologists and has products suitable for dry skin, sensitive skin, oily skin, acne-prone, and more.

Things to Consider When Buying the Best Drugstore Night Creams for Acne Prone Skin

Ingredients

When it comes to choosing the best drugstore night cream for acne prone skin, the most important thing to consider is the ingredients. If you’re particularly allergic to a specific ingredient, make sure to only choose products that don’t contain it. This way, you won’t experience allergies or irritation when using a drugstore night cream.

Price

Another important thing to consider is the price. You shouldn’t always chase the cheapest product on the market as it can cause problems in the long run. Similarly, just because a product is expensive doesn’t mean that it’s the right product for you. Make sure to do your due diligence when shopping for the best drugstore night cream for acne prone skin.

Avoid Harsh Chemicals

When looking for the best drugstore night cream for acne prone skin, it’s better to avoid harsh chemicals. Generally, it’s better to look for a product that doesn’t contain synthetic fragrances, parabens, sulfates, phthalates, etc. Even the reputable products can sometimes contain these chemicals, it’s important to look at the formula. Too much of these chemicals can be bad for you.

Star Rating

If a product is well-received on Amazon, chances are it’s usually pretty good. These reviews are generally a testament to the efficacy of a product. When shopping for the best drugstore night cream for acne prone skin, you should usually go with product with the star rating of 3. 5 or more. The higher the better!

Read Customer Reviews

Reading customer reviews can also be helpful when purchasing the best drugstore night cream for acne prone skin. It’s possible that someone else who has the same needs as you has already tried and reviewed the product. Reading their review will give you an idea on whether or not the drugstore night cream you’re looking to buy is worth your time and money.

Brand Name

Finally, when it comes to beauty, skincare, or hair care products, it’s usually better to stick with reputable products. There are so many products available on the market, but the brands which have stood the test of time are the ones that you should generally go for. At the same time, don’t be afraid of experimenting with new products.

Patch Test

No matter which drugstore night cream you’re considering, it’s important to do a patch test first (even if a product is well-received). Everyone is different and so are their needs. So, always be sure to do a patch test when you try out a new product.

Conclusion

It can be challenging to find the best drugstore night cream for acne prone skin. However, we’ve done all the heavy-lifting for you. We hope this article helped you find the best drugstore night cream for your needs.

Which one of these drugstore night creams are you going to try? Let us know in the comments below. If you have any questions, ask away.

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